Diagnostics of the hepatic fibrosis and cirrhosis in children by means of serum markers

Abstract

Possibilities of application of hyaluronic acid and type IV collagen levels in serum for noninvasive diagnostics of various stages of hepatic fibrosis in children with chronic liver diseases are studied. It is established that serum concentration of these biochemical markers significantly change at the expressed sclerotic processes in hepatic tissue. Hyaluronic acid and type IV collagen are reliable noninvasive markers of severe fibrosis and cirrhosis of liver, can be used in pediatric practice for specification of a stage of process in hepatic parenchyma at impossibility of carrying out liver biopsy, and also for an estimation of dynamics of fibrosis and monitoring of efficiency of therapy at chronic liver diseases.

Keywords

• гиалуроновая кислота
• коллаген IV типа
• цирроз печени
• диагностика
• дети