Interplay between cardiovascular and thyroid dysfunctions: A review of clinical implications and management strategies

Abstract

Cardiovascular diseases (CVD) and thyroid dysfunction are two of the most prevailing disorders in the world that are closely interlinked. Actions of thyroid hormones are mediated via thyroid receptors present in the myocardium and the vascular tissue. Primary mechanism that links thyroid dysfunction with CVD is the modification of cardiovascular risk factors (dyslipidemia, blood pressure, coagulation parameters, etc.) resulting in endothelial and left ventricular systolic and diastolic dysfunction.

Keywords

• cardiovascular disease
• heart failure
• hyperthyroidism
• hypothyroidism
• subclinical thyroid dysfunction
• thyroid hormones