Scientific Reports (Jan 2021)

Estimation of the hemoglobin glycation rate constant

  • Masashi Kameyama,
  • Toshika Okumiya,
  • Shinji Tokuhiro,
  • Yoshihisa Matsumura,
  • Hirotaka Matsui,
  • Yasuhiro Ono,
  • Tsuyoshi Iwasaka,
  • Kazuyuki Hiratani,
  • Masafumi Koga

DOI
https://doi.org/10.1038/s41598-020-80024-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 6

Abstract

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Abstract In a previous study, a method of obtaining mean erythrocyte age ( $$M_{RBC}$$ M RBC ) from HbA1c and average plasma glucose (AG) was proposed. However, the true value of the hemoglobin glycation constant ( $$k_g$$ k g dL/mg/day), required for this model has yet to be well characterized. Another study also proposed a method of deriving $$M_{RBC}$$ M RBC from erythrocyte creatine (EC). Utilizing these formulae, this study aimed to determine a more accurate estimate of $$k_g$$ k g . One hundred and seven subjects including 31 patients with hemolytic anemia and 76 subjects without anemia were included in this study. EC and HbA1c data were analyzed, and $$M_{RBC}$$ M RBC using HbA1c, AG and the newly-derived constant, $$k_g$$ k g were compared to $$M_{RBC}$$ M RBC using traditional $$^{51}\hbox {Cr}$$ 51 Cr in three patients whose data were taken from previous case studies. A value of $$7.0\times 10^{-6}$$ 7.0 × 10 - 6 dL/mg/day was determined for $$k_g$$ k g . $$M_{RBC}$$ M RBC using HbA1c, AG and $$k_g$$ k g were found to no be significantly different (paired t-test, $$p=0.45$$ p = 0.45 ) to $$M_{RBC}$$ M RBC using traditional $$^{51}\hbox {Cr}$$ 51 Cr . $$k_g$$ k g enables the estimation of $$M_{RBC}$$ M RBC from HbA1c and AG.