An Investigation of the Secretion Rate of Plasma Chemerin and its Effect on Insulin Resistance Index after 8 Weeks of Resistance Exercise in Male Rats

Abstract

Background and Objectives : Chemerin is a newly discovered adipokine, which induce insulin resistance in skeletal muscles. The present study examined the secretion rate of plasma chemerin and its effect on insulin resistance index after 8 weeks of resistance exercise in male rats. Methods: In this study, 24 male Wister rats (mean weight, 161±23g and age, 5 weeks) were randomly divided into three groups of 8 each (healthy control, insulin-resistant control, and insulin-resistant training). A resistance training program was performed, including climbing a ladder carrying a load suspended from the tail (3 days/week, for 8 week). After 8 weeks of resistance training, the rats were anesthetized and sampling was performed. The levels of chemerin, insulin, and fasting blood glucose and insulin resistance index were measured. Data were analyzed using one-way ANOVA. The significance level was considered to be p<0.05. Results: Chemerin levels significantly decreased (p=0.01) in resistance training group. Also, a significant reductions was observed in plasma levels of glucose (p<0.001) and insulin (p<0.001). Resistance training reduced Insulin resistance index (p<0.0001). Conclusion: According to the results of this study, it seems that resistance training can be considered as an important factor in reducing chemerin levels and improving insulin sensitivity.

Keywords

• chemerin
• insulin resistance
• resistance training
• rats