IMPACT OF TUMOR GRADE ON SURVIVAL AND PROGNOSIS OF THE EARLY EPITHELIAL OVARIAN CANCER

Abstract

PURPOSE: To analyze the role of the grade of the tumor as a prognostic factor for women with early epithelial ovarian cancer MATHERIAL AND METHODS: For the purpose of the research, a cohort of 254 female patients with ovarian cancer (stage I- II) was investigated for a 12 year period (2000- 2012). All of the patients were surgically staged, and have histopathology result for morphology type and degree of differentiation (grade) of the tumor. For the purpose of our research we used descriptive analysis, Variation analysis, Correlative analysis, Covariate analysis, Graphic analysis, Kaplan – Mayer analysis, Chi – square – analysis. RESULTS: In multivariate analysis with eighteen others potential factors the tumor grade proved to be an independent prognostic factor for overall- and progression free survival of female patients with early epithelial ovarian cancer along with age, stage and tumor markers. CONCLUSIONS: 1. The tumor grade is a reliable predictor of survival for patients with early epithelial ovarian cancer. 2. There is a point the grading system to consist of only two grades. It allows us to quickly distinguish the patients at higher risk from those at relatively low risk, which can reflect in the aggressiveness of the treatment. 3. Because of the definite early recurrence of disease patients with high- grade ovarian tumors that survived more than five years, we can consider being cured.

Keywords

• epithelial ovarian cancer
• survival
• prognosis
• tumor grade
• prognostic factor