Nature Communications (Mar 2018)

Scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds

  • Lizhi Zhu,
  • Wenjing Ma,
  • Mengxun Zhang,
  • Magnolia Muk-Lan Lee,
  • Wing-Yan Wong,
  • Brandon Dow Chan,
  • Qianqian Yang,
  • Wing-Tak Wong,
  • William Chi-Shing Tai,
  • Chi-Sing Lee

DOI
https://doi.org/10.1038/s41467-018-03546-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Isodon diterpenoids, promising anti-cancer agents found in certain tropical plants, are difficult to obtain. Here, the authors developed a synthetic strategy to synthesise several different members of this group, including neolaxiflorin L which emerged from this study as a promising drug candidate.