Nature Communications (Dec 2022)
Dysfunctional Sars-CoV-2-M protein-specific cytotoxic T lymphocytes in patients recovering from severe COVID-19
- Hideki Ogura,
- Jin Gohda,
- Xiuyuan Lu,
- Mizuki Yamamoto,
- Yoshio Takesue,
- Aoi Son,
- Sadayuki Doi,
- Kazuyuki Matsushita,
- Fumitaka Isobe,
- Yoshihiro Fukuda,
- Tai-Ping Huang,
- Takamasa Ueno,
- Naomi Mambo,
- Hiromoto Murakami,
- Yasushi Kawaguchi,
- Jun-ichiro Inoue,
- Kunihiro Shirai,
- Sho Yamasaki,
- Jun-Ichi Hirata,
- Satoshi Ishido
Affiliations
- Hideki Ogura
- Department of Microbiology, Hyogo Medical University
- Jin Gohda
- Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo
- Xiuyuan Lu
- Laboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University
- Mizuki Yamamoto
- Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo
- Yoshio Takesue
- Department of Infection Control and Prevention, Hyogo Medical University
- Aoi Son
- Department of Microbiology, Hyogo Medical University
- Sadayuki Doi
- Kawanishi City Hospital
- Kazuyuki Matsushita
- Kyoritsu Hospital
- Fumitaka Isobe
- Kyowa Marina Hospital/Wellhouse Nishinomiya
- Yoshihiro Fukuda
- Dainikyoritsu Hospital
- Tai-Ping Huang
- Kyoritsu Onsen Hospital
- Takamasa Ueno
- Joint Research Center for Human Retrovirus Infection, Kumamoto University
- Naomi Mambo
- Department of Emergency and Critical Care Medicine, Hyogo Medical University
- Hiromoto Murakami
- Department of Emergency and Critical Care Medicine, Hyogo Medical University
- Yasushi Kawaguchi
- Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo
- Jun-ichiro Inoue
- Research Platform Office, The Institute of Medical Science, The University of Tokyo
- Kunihiro Shirai
- Department of Emergency and Critical Care Medicine, Hyogo Medical University
- Sho Yamasaki
- Laboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University
- Jun-Ichi Hirata
- Department of Emergency and Critical Care Medicine, Hyogo Medical University
- Satoshi Ishido
- Department of Microbiology, Hyogo Medical University
- DOI
- https://doi.org/10.1038/s41467-022-34655-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Cytotoxic T lymphocytes play important roles in the anti-viral immune response in COVID-19, and it is important to know how they contribute to disease outcome. Authors here identify a dominant SARS-CoV-2 M protein epitope, M198–206, and show that M198–206-specific cytotoxic T cells from convalescent patients with severe disease harbour a gene expression pattern indicative of poor functionality.
