Nature Communications (Apr 2016)

Aurora A drives early signalling and vesicle dynamics during T-cell activation

  • Noelia Blas-Rus,
  • Eugenio Bustos-Morán,
  • Ignacio Pérez de Castro,
  • Guillermo de Cárcer,
  • Aldo Borroto,
  • Emilio Camafeita,
  • Inmaculada Jorge,
  • Jesús Vázquez,
  • Balbino Alarcón,
  • Marcos Malumbres,
  • Noa B. Martín-Cófreces,
  • Francisco Sánchez-Madrid

DOI
https://doi.org/10.1038/ncomms11389
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 16

Abstract

Read online

Aurora A is a protein kinase that contributes to the progression of mitosis by stimulating microtubule nucleation. Here the authors show that Aurora A also functions during T cell activation by maintaining TCR signaling through Lck activation.