Nature Communications (Jul 2021)
SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
- Charlotte Martinat,
- Arthur Cormier,
- Joëlle Tobaly-Tapiero,
- Noé Palmic,
- Nicoletta Casartelli,
- Bijan Mahboubi,
- Si’Ana A. Coggins,
- Julian Buchrieser,
- Mirjana Persaud,
- Felipe Diaz-Griffero,
- Lucile Espert,
- Guillaume Bossis,
- Pascale Lesage,
- Olivier Schwartz,
- Baek Kim,
- Florence Margottin-Goguet,
- Ali Saïb,
- Alessia Zamborlini
Affiliations
- Charlotte Martinat
- INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis
- Arthur Cormier
- INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis
- Joëlle Tobaly-Tapiero
- INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis
- Noé Palmic
- INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis
- Nicoletta Casartelli
- Institut Pasteur, Virus and Immunity Unit, CNRS-UMR3569
- Bijan Mahboubi
- Emory School of Medicine
- Si’Ana A. Coggins
- Emory School of Medicine
- Julian Buchrieser
- Institut Pasteur, Virus and Immunity Unit, CNRS-UMR3569
- Mirjana Persaud
- Albert Einstein College of Medicine, Microbiology and Immunology
- Felipe Diaz-Griffero
- Albert Einstein College of Medicine, Microbiology and Immunology
- Lucile Espert
- IRIM, University of Montpellier, UMR 9004 CNRS
- Guillaume Bossis
- IGMM, Univ Montpellier, CNRS
- Pascale Lesage
- INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis
- Olivier Schwartz
- Institut Pasteur, Virus and Immunity Unit, CNRS-UMR3569
- Baek Kim
- Emory School of Medicine
- Florence Margottin-Goguet
- Université de Paris, Institut Cochin, INSERM, CNRS
- Ali Saïb
- INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis
- Alessia Zamborlini
- INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis
- DOI
- https://doi.org/10.1038/s41467-021-24802-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
SAMHD1 is a cellular dNTPase proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting dNTP substrate supply; its anti-viral but not dNTPase function is downregulated by phosphorylation of T592. Here, Martinat et al. describe an additional SUMOylation at residue K595, which promotes the dNTPase-independent restriction activity.
