Nature Communications (Feb 2018)
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction
- Janin Lautenschläger,
- Amberley D. Stephens,
- Giuliana Fusco,
- Florian Ströhl,
- Nathan Curry,
- Maria Zacharopoulou,
- Claire H. Michel,
- Romain Laine,
- Nadezhda Nespovitaya,
- Marcus Fantham,
- Dorothea Pinotsi,
- Wagner Zago,
- Paul Fraser,
- Anurag Tandon,
- Peter St George-Hyslop,
- Eric Rees,
- Jonathan J. Phillips,
- Alfonso De Simone,
- Clemens F. Kaminski,
- Gabriele S. Kaminski Schierle
Affiliations
- Janin Lautenschläger
- Department of Chemical Engineering and Biotechnology, University of Cambridge
- Amberley D. Stephens
- Department of Chemical Engineering and Biotechnology, University of Cambridge
- Giuliana Fusco
- Department of Chemistry, University of Cambridge
- Florian Ströhl
- Department of Chemical Engineering and Biotechnology, University of Cambridge
- Nathan Curry
- Department of Chemical Engineering and Biotechnology, University of Cambridge
- Maria Zacharopoulou
- Department of Chemical Engineering and Biotechnology, University of Cambridge
- Claire H. Michel
- Department of Chemical Engineering and Biotechnology, University of Cambridge
- Romain Laine
- Department of Chemical Engineering and Biotechnology, University of Cambridge
- Nadezhda Nespovitaya
- Department of Chemical Engineering and Biotechnology, University of Cambridge
- Marcus Fantham
- Department of Chemical Engineering and Biotechnology, University of Cambridge
- Dorothea Pinotsi
- Department of Chemical Engineering and Biotechnology, University of Cambridge
- Wagner Zago
- Prothena Biosciences Inc
- Paul Fraser
- Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto
- Anurag Tandon
- Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto
- Peter St George-Hyslop
- Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto
- Eric Rees
- Department of Chemical Engineering and Biotechnology, University of Cambridge
- Jonathan J. Phillips
- Department of Biosciences, Living Systems Institute, University of Exeter
- Alfonso De Simone
- Department of Life Sciences, Imperial College London
- Clemens F. Kaminski
- Department of Chemical Engineering and Biotechnology, University of Cambridge
- Gabriele S. Kaminski Schierle
- Department of Chemical Engineering and Biotechnology, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-018-03111-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Alpha-synuclein is associated with neuronal dysfunction in Parkinson’s disease. This study shows that alpha-synuclein interacts with neuronal synaptic vesicles in a calcium-dependent fashion, and this interaction is important for synaptic vesicle clustering.
