A pandemic-enabled comparison of discovery platforms demonstrates a naïve antibody library can match the best immune-sourced antibodies

Fortunato Ferrara; M. Frank Erasmus; Sara D’Angelo; Camila Leal-Lopes; André A. Teixeira; Alok Choudhary; William Honnen; David Calianese; Deli Huang; Linghan Peng; James E. Voss; David Nemazee; Dennis R. Burton; Abraham Pinter; Andrew R. M. Bradbury

doi:10.1038/s41467-021-27799-z

Nature Communications (Jan 2022)

A pandemic-enabled comparison of discovery platforms demonstrates a naïve antibody library can match the best immune-sourced antibodies

Fortunato Ferrara,
M. Frank Erasmus,
Sara D’Angelo,
Camila Leal-Lopes,
André A. Teixeira,
Alok Choudhary,
William Honnen,
David Calianese,
Deli Huang,
Linghan Peng,
James E. Voss,
David Nemazee,
Dennis R. Burton,
Abraham Pinter,
Andrew R. M. Bradbury

Affiliations

Fortunato Ferrara: Specifica Inc
M. Frank Erasmus: Specifica Inc
Sara D’Angelo: Specifica Inc
Camila Leal-Lopes: Bioscience Division, New Mexico Consortium
André A. Teixeira: Bioscience Division, New Mexico Consortium
Alok Choudhary: Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey
William Honnen: Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey
David Calianese: Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey
Deli Huang: Life Sciences Institute, Zhejiang University
Linghan Peng: Department of Immunology and Microbiology, The Scripps Research Institute
James E. Voss: Department of Immunology and Microbiology, The Scripps Research Institute
David Nemazee: Department of Immunology and Microbiology, The Scripps Research Institute
Dennis R. Burton: Department of Immunology and Microbiology, The Scripps Research Institute
Abraham Pinter: Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey
Andrew R. M. Bradbury: Specifica Inc

DOI: https://doi.org/10.1038/s41467-021-27799-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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The most potent neutralizing antibodies are typically generated from convalescent patients and immunized animals. Here, the authors show it is possible to generate highly potent human neutralizing antibodies against the SARS-CoV-2 spike protein directly from a semisynthetic naïve antibody library.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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