4-(Benzo[<i>d</i>]thiazol-2-yl)-1-(2-nitrophenyl)-1<i>H</i>-1,2,3-triazol-5-amine

Abstract

The protocol for the reaction of 2-nitrophenyl azide with 2-(benzo[d]thiazol-2-yl)acetonitrile has been selected. It was found that an optimal condition under which the target 4-(benzo[d]thiazol-2-yl)-1-(2-nitrophenyl)-1H-1,2,3-triazol-5-amine could be formed in good yield is the triethylamine system as a base in the DMF solution. The synthesized triazole is promising both for the evaluation of its antiproliferative properties and for the study of the path to new ring annulation by transforming nitro and amino groups.

Keywords

• aryl azides
• 2-(benzo[<i>d</i>]thiazol-2-yl)acetonitrile
• 1,2,3-triazoles
• Dimroth cyclization
• organocatalysis