Nature Communications (May 2019)
Association analyses identify 31 new risk loci for colorectal cancer susceptibility
- Philip J. Law,
- Maria Timofeeva,
- Ceres Fernandez-Rozadilla,
- Peter Broderick,
- James Studd,
- Juan Fernandez-Tajes,
- Susan Farrington,
- Victoria Svinti,
- Claire Palles,
- Giulia Orlando,
- Amit Sud,
- Amy Holroyd,
- Steven Penegar,
- Evropi Theodoratou,
- Peter Vaughan-Shaw,
- Harry Campbell,
- Lina Zgaga,
- Caroline Hayward,
- Archie Campbell,
- Sarah Harris,
- Ian J. Deary,
- John Starr,
- Laura Gatcombe,
- Maria Pinna,
- Sarah Briggs,
- Lynn Martin,
- Emma Jaeger,
- Archana Sharma-Oates,
- James East,
- Simon Leedham,
- Roland Arnold,
- Elaine Johnstone,
- Haitao Wang,
- David Kerr,
- Rachel Kerr,
- Tim Maughan,
- Richard Kaplan,
- Nada Al-Tassan,
- Kimmo Palin,
- Ulrika A. Hänninen,
- Tatiana Cajuso,
- Tomas Tanskanen,
- Johanna Kondelin,
- Eevi Kaasinen,
- Antti-Pekka Sarin,
- Johan G. Eriksson,
- Harri Rissanen,
- Paul Knekt,
- Eero Pukkala,
- Pekka Jousilahti,
- Veikko Salomaa,
- Samuli Ripatti,
- Aarno Palotie,
- Laura Renkonen-Sinisalo,
- Anna Lepistö,
- Jan Böhm,
- Jukka-Pekka Mecklin,
- Daniel D. Buchanan,
- Aung-Ko Win,
- John Hopper,
- Mark E. Jenkins,
- Noralane M. Lindor,
- Polly A. Newcomb,
- Steven Gallinger,
- David Duggan,
- Graham Casey,
- Per Hoffmann,
- Markus M. Nöthen,
- Karl-Heinz Jöckel,
- Douglas F. Easton,
- Paul D. P. Pharoah,
- Julian Peto,
- Federico Canzian,
- Anthony Swerdlow,
- Rosalind A. Eeles,
- Zsofia Kote-Jarai,
- Kenneth Muir,
- Nora Pashayan,
- The PRACTICAL consortium,
- Andrea Harkin,
- Karen Allan,
- John McQueen,
- James Paul,
- Timothy Iveson,
- Mark Saunders,
- Katja Butterbach,
- Jenny Chang-Claude,
- Michael Hoffmeister,
- Hermann Brenner,
- Iva Kirac,
- Petar Matošević,
- Philipp Hofer,
- Stefanie Brezina,
- Andrea Gsur,
- Jeremy P. Cheadle,
- Lauri A. Aaltonen,
- Ian Tomlinson,
- Richard S. Houlston,
- Malcolm G. Dunlop
Affiliations
- Philip J. Law
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Maria Timofeeva
- Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh
- Ceres Fernandez-Rozadilla
- Grupo de Medicina Xenómica, Fundación Pública Galega de Medicina Xenómica, Instituto de Investigación de Santiago
- Peter Broderick
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- James Studd
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Juan Fernandez-Tajes
- Wellcome Centre for Human Genetics, McCarthy Group
- Susan Farrington
- Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh
- Victoria Svinti
- Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh
- Claire Palles
- Gastrointestinal Cancer Genetics Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham
- Giulia Orlando
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Amit Sud
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Amy Holroyd
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Steven Penegar
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Evropi Theodoratou
- Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh
- Peter Vaughan-Shaw
- Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh
- Harry Campbell
- Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh
- Lina Zgaga
- Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh
- Caroline Hayward
- Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh
- Archie Campbell
- Generation Scotland, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
- Sarah Harris
- Generation Scotland, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
- Ian J. Deary
- Generation Scotland, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
- John Starr
- Generation Scotland, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
- Laura Gatcombe
- Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham
- Maria Pinna
- Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham
- Sarah Briggs
- Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham
- Lynn Martin
- Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham
- Emma Jaeger
- Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham
- Archana Sharma-Oates
- Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham
- James East
- Translational Gastroenterology Unit, Nuffield Department. of Medicine, University of Oxford, John Radcliffe Hospital
- Simon Leedham
- Wellcome Centre for Human Genetics, McCarthy Group
- Roland Arnold
- Cancer Bioinfomatics Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham
- Elaine Johnstone
- Department of Oncology, University of Oxford
- Haitao Wang
- Department of Oncology, University of Oxford
- David Kerr
- Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford
- Rachel Kerr
- Department of Oncology, University of Oxford
- Tim Maughan
- Department of Oncology, University of Oxford
- Richard Kaplan
- Medical Research Council Clinical Trials Unit
- Nada Al-Tassan
- Department of Genetics, King Faisal Specialist Hospital and Research Center
- Kimmo Palin
- Department of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki
- Ulrika A. Hänninen
- Department of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki
- Tatiana Cajuso
- Department of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki
- Tomas Tanskanen
- Department of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki
- Johanna Kondelin
- Department of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki
- Eevi Kaasinen
- Department of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki
- Antti-Pekka Sarin
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Johan G. Eriksson
- Folkhälsan Research Centre
- Harri Rissanen
- National Institute for Health and Welfare
- Paul Knekt
- National Institute for Health and Welfare
- Eero Pukkala
- Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland, and Faculty of Social Sciences, University of Tampere
- Pekka Jousilahti
- National Institute for Health and Welfare
- Veikko Salomaa
- National Institute for Health and Welfare
- Samuli Ripatti
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Aarno Palotie
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Laura Renkonen-Sinisalo
- Department of Surgery, Abdominal Center, Helsinki University Hospital
- Anna Lepistö
- Department of Surgery, Abdominal Center, Helsinki University Hospital
- Jan Böhm
- Department of Pathology, Central Finland Central Hospital
- Jukka-Pekka Mecklin
- Department of Surgery, Jyväskylä Central Hospital
- Daniel D. Buchanan
- Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne
- Aung-Ko Win
- Centre for Epidemiology and Biostatistics, The University of Melbourne
- John Hopper
- Centre for Epidemiology and Biostatistics, The University of Melbourne
- Mark E. Jenkins
- Centre for Epidemiology and Biostatistics, The University of Melbourne
- Noralane M. Lindor
- Department of Health Sciences Research, Mayo Clinic
- Polly A. Newcomb
- Cancer Prevention Program, Fred Hutchinson Cancer Research Center
- Steven Gallinger
- Mount Sinai Hospital, Lunenfeld-Tanenbaum Research Institute
- David Duggan
- Translational Genomics Research Institute (TGen), An Affiliate of City of Hope
- Graham Casey
- Center for Public Health Genomics, University of Virginia
- Per Hoffmann
- Human Genomics Research Group, Department of Biomedicine, University of Basel
- Markus M. Nöthen
- Department of Genomics, Life & Brain Center, University of Bonn
- Karl-Heinz Jöckel
- Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen
- Douglas F. Easton
- Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge
- Paul D. P. Pharoah
- Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge
- Julian Peto
- Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine
- Federico Canzian
- Genomic Epidemiology Group, German Cancer Research Center (DKFZ)
- Anthony Swerdlow
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Rosalind A. Eeles
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Zsofia Kote-Jarai
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Kenneth Muir
- Division of Population Health, Health Services Research and Primary Care, University of Manchester
- Nora Pashayan
- Department of Applied Health Research, University College London
- The PRACTICAL consortium
- Andrea Harkin
- Cancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow
- Karen Allan
- Cancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow
- John McQueen
- Cancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow
- James Paul
- Cancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow
- Timothy Iveson
- University Hospital Southampton NHS Foundation Trust
- Mark Saunders
- The Christie NHS Foundation Trust
- Katja Butterbach
- Division of Clinical Epidemiology and Aging Research, Deutsches Krebsforschungszentrum
- Jenny Chang-Claude
- Unit of Genetic Epidemiology, German Cancer Research Center (DKFZ)
- Michael Hoffmeister
- Division of Clinical Epidemiology and Aging Research, Deutsches Krebsforschungszentrum
- Hermann Brenner
- Division of Clinical Epidemiology and Aging Research, Deutsches Krebsforschungszentrum
- Iva Kirac
- Department of Surgical Oncology, University Hospital for Tumours, Sestre milosrdnice University Hospital Centre
- Petar Matošević
- Department of Surgery, University Hospital Center Zagreb
- Philipp Hofer
- Department of Medicine I, Institute of Cancer Research, Medical University of Vienna
- Stefanie Brezina
- Department of Medicine I, Institute of Cancer Research, Medical University of Vienna
- Andrea Gsur
- Department of Medicine I, Institute of Cancer Research, Medical University of Vienna
- Jeremy P. Cheadle
- Division of Cancer and Genetics, School of Medicine, Cardiff University
- Lauri A. Aaltonen
- Department of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki
- Ian Tomlinson
- Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham
- Richard S. Houlston
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Malcolm G. Dunlop
- Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh
- DOI
- https://doi.org/10.1038/s41467-019-09775-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
In colorectal cancer (CRC), finding loci associated with risk may give insight into disease aetiology. Here, the authors report a genome-wide association analysis in Europeans of 34,627 CRC cases and 71,379 controls, and find 31 new risk loci and 17 new risk SNPs at previously reported loci.
