Urology Case Reports (May 2018)

Primary amelanotic malignant melanoma of the male urethra with inguinal lymph node metastasis successfully controlled by nivolumab: A case report

  • Takashi Tokita,
  • Takashi Kawahara,
  • Yusuke Ito,
  • Sohgo Tsutsumi,
  • Koichi Abe,
  • Kazuhiro Namura,
  • Futoshi Sano,
  • Koichi Shioi,
  • Daiji Takamoto,
  • Yasushi Yumura,
  • Noboru Nakaigawa,
  • Masahiro Yao,
  • Hiroji Uemura,
  • Hidefumi Wada,
  • Yukio Tsuura,
  • Kazuki Kobayashi

Journal volume & issue
Vol. 18
pp. 54 – 56

Abstract

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We report a rare case of primary amelanotic malignant melanoma of the male urethra. A 65-year-old man with a urethral mass was referred to our hospital. A pathological diagnosis of a biopsy specimen revealed malignant melanoma. Thereafter, the patient underwent partial penectomy. The histopathological diagnosis was amelanotic malignant melanoma of the urethra. The patient had received DAV-Feron in an adjuvant setting; however, PET-CT revealed multiple metastasis. After receiving more than 10 cycles of nivolumab, the accumulation of FDG was no longer observed on PET-CT. The patient is currently free from recurrence at 20 months after nivolumab treatment. Keywords: Melanoma, Urethral neoplasm, Inguinal lymphadenectomy, Nivolumab