Nature Communications (Nov 2020)
Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease
- Marta Olah,
- Vilas Menon,
- Naomi Habib,
- Mariko F. Taga,
- Yiyi Ma,
- Christina J. Yung,
- Maria Cimpean,
- Anthony Khairallah,
- Guillermo Coronas-Samano,
- Roman Sankowski,
- Dominic Grün,
- Alexandra A. Kroshilina,
- Danielle Dionne,
- Rani A. Sarkis,
- Garth R. Cosgrove,
- Jeffrey Helgager,
- Jeffrey A. Golden,
- Page B. Pennell,
- Marco Prinz,
- Jean Paul G. Vonsattel,
- Andrew F. Teich,
- Julie A. Schneider,
- David A. Bennett,
- Aviv Regev,
- Wassim Elyaman,
- Elizabeth M. Bradshaw,
- Philip L. De Jager
Affiliations
- Marta Olah
- Center for Translational and Computational Neuroimmunology, Columbia University Medical Center
- Vilas Menon
- Center for Translational and Computational Neuroimmunology, Columbia University Medical Center
- Naomi Habib
- Cell Circuits Program, Broad Institute
- Mariko F. Taga
- Center for Translational and Computational Neuroimmunology, Columbia University Medical Center
- Yiyi Ma
- Center for Translational and Computational Neuroimmunology, Columbia University Medical Center
- Christina J. Yung
- Center for Translational and Computational Neuroimmunology, Columbia University Medical Center
- Maria Cimpean
- Center for Translational and Computational Neuroimmunology, Columbia University Medical Center
- Anthony Khairallah
- Center for Translational and Computational Neuroimmunology, Columbia University Medical Center
- Guillermo Coronas-Samano
- Taub Institute for Research on Alzheimer’s Disease and Aging Brain, Columbia University Medical Center
- Roman Sankowski
- Institute of Neuropathology, Medical Faculty, University of Freiburg
- Dominic Grün
- Max-Planck-Institute of Immunobiology and Epigenetics
- Alexandra A. Kroshilina
- Center for Translational and Computational Neuroimmunology, Columbia University Medical Center
- Danielle Dionne
- Cell Circuits Program, Broad Institute
- Rani A. Sarkis
- Department of Neurology, Brigham and Women’s Hospital
- Garth R. Cosgrove
- Department of Neurosurgery, Brigham and Women’s Hospital
- Jeffrey Helgager
- Department of Pathology, Brigham and Women’s Hospital
- Jeffrey A. Golden
- Department of Pathology, Brigham and Women’s Hospital
- Page B. Pennell
- Department of Neurology, Brigham and Women’s Hospital
- Marco Prinz
- Institute of Neuropathology, Medical Faculty, University of Freiburg
- Jean Paul G. Vonsattel
- Taub Institute for Research on Alzheimer’s Disease and Aging Brain, Columbia University Medical Center
- Andrew F. Teich
- Taub Institute for Research on Alzheimer’s Disease and Aging Brain, Columbia University Medical Center
- Julie A. Schneider
- Rush Alzheimer’s Disease Center, Rush University Medical Center
- David A. Bennett
- Rush Alzheimer’s Disease Center, Rush University Medical Center
- Aviv Regev
- Cell Circuits Program, Broad Institute
- Wassim Elyaman
- Taub Institute for Research on Alzheimer’s Disease and Aging Brain, Columbia University Medical Center
- Elizabeth M. Bradshaw
- Taub Institute for Research on Alzheimer’s Disease and Aging Brain, Columbia University Medical Center
- Philip L. De Jager
- Center for Translational and Computational Neuroimmunology, Columbia University Medical Center
- DOI
- https://doi.org/10.1038/s41467-020-19737-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Imbalance of microglial phenotypes in the aging brain might underlie their involvement in late onset neurodegenerative diseases. Here we report the population structure of microglia in the aged human brain and the reduction of a particular microglia subset in individuals with Alzheimer’s disease .
