Communications Biology (Feb 2022)
Cell biological analysis reveals an essential role for Pfcerli2 in erythrocyte invasion by malaria parasites
- Benjamin Liffner,
- Juan Miguel Balbin,
- Gerald J. Shami,
- Ghizal Siddiqui,
- Jan Strauss,
- Sonja Frölich,
- Gary K. Heinemann,
- Ella May Edwards,
- Arne Alder,
- Jan Stephan Wichers,
- Darren J. Creek,
- Leann Tilley,
- Matthew W. A. Dixon,
- Tim-Wolf Gilberger,
- Danny W. Wilson
Affiliations
- Benjamin Liffner
- Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide
- Juan Miguel Balbin
- Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide
- Gerald J. Shami
- Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne
- Ghizal Siddiqui
- Dept Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University
- Jan Strauss
- Centre for Structural Systems Biology
- Sonja Frölich
- Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide
- Gary K. Heinemann
- Experimental Therapeutics Laboratory, Clinical and Health Science Unit, University of South Australia
- Ella May Edwards
- Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide
- Arne Alder
- Centre for Structural Systems Biology
- Jan Stephan Wichers
- Centre for Structural Systems Biology
- Darren J. Creek
- Dept Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University
- Leann Tilley
- Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne
- Matthew W. A. Dixon
- Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne
- Tim-Wolf Gilberger
- Centre for Structural Systems Biology
- Danny W. Wilson
- Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide
- DOI
- https://doi.org/10.1038/s42003-022-03020-9
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 17
Abstract
Benjamin Liffner and Miguel Balbin et al. report that the Plasmodium falciparum protein, PfCERLI2, localises to the cytosolic face of the parasite’s rhoptry bulb and is essential for invasion and growth within human red blood cells.
