Potential Role of CHAC1 in Malignant Progression of Bladder Urothelial Carcinoma

Abstract

Objective To investigate the biological characteristics and clinical relevance of CHAC1 in bladder urothelial carcinoma(BLCA). Methods The original data of CHAC1 was obtained from the Cancer Genome Atlas and the Human Protein Atlas.R software,MEXPRESS platform and TISIDB platform were used for gene expression analysis,survival analysis, copy number variation and methylation analysis,gene enrichment analysis and immune infiltration analysis of CHAC1. Results Compared with normal tissues,CHAC1 is abnormally expressed in a variety of tumor tissues(P<0.05),especially in BLCA(P<0.001).High expression of CHAC1 predicts poor prognosis of BLCA,which is related to CHAC1 hypomethylation level.CHAC1 enrichment analysis showed that it was involved in a variety of metabolism-related biological processes,including amino acid metabolism and GSH metabolism.The expression level of CHAC1 in BLCA was associated with excessive infiltration of a variety of immune cells,including dendritic cells,activated dendritic cells,neutrophils,macrophages,regulatory T cells,Th1 cells,Th2 cells,B cells,and NK CD56dim cells. Conclusion CHAC1 may become a potential biomarker and therapeutic target for evaluating BLCA prognosis and modulating levels of immune infiltration.

Keywords

• chac1
• bladder urothelial carcinoma
• immune features
• biomarker