The potential of organic piezoelectric materials for next-generation implantable biomedical devices
Arshad Khan,
Ravindra Joshi,
Manish Kumar Sharma,
Chun-Ju Huang,
Jui-Han Yu,
Yu-Lin Wang,
Zong-Hong Lin
Affiliations
Arshad Khan
Department of Biomedical Engineering, National Taiwan University, Taipei 10167, Taiwan; International Intercollegiate PhD Program, National Tsing Hua University, Hsinchu 30013, Taiwan
Ravindra Joshi
Department of Biomedical Engineering, National Taiwan University, Taipei 10167, Taiwan; Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan
Manish Kumar Sharma
Department of Biomedical Engineering, National Taiwan University, Taipei 10167, Taiwan; Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan
Chun-Ju Huang
Department of Biomedical Engineering, National Taiwan University, Taipei 10167, Taiwan; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan
Jui-Han Yu
Department of Biomedical Engineering, National Taiwan University, Taipei 10167, Taiwan; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan
Yu-Lin Wang
Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan; Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Hsinchu 30013, Taiwan
Zong-Hong Lin
Department of Biomedical Engineering, National Taiwan University, Taipei 10167, Taiwan; Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan; Internet of Senses Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan; Corresponding author.
Piezoelectricity or piezoelectric effect is a phenomenon by which mechanical energy is converted into electrical energy and vice versa. Piezoelectric effect has been observed in several organic materials. Therefore, in past few years organic piezoelectric materials have received significant research interests in biomedical applications and specifically for fabrication of implantable biomedical devices because of their high piezoelectric performance, excellent biocompatibility and biodegradability, superior mechanical properties, and cheap fabrication process. This article provides a comprehensive review of the recent research progress on organic piezoelectric materials. It extensively covers the piezoelectric properties and preparation methods of different organic piezoelectric materials including amino acids, peptides, proteins, polysaccharides, and polymers (such as PVDF, PLLA, PHB), as well as their representative implantable biomedical device applications namely biosensing, tissue regeneration, and drug delivery. Finally, the article discusses the challenges and future directions of this research field.
