CYTOKINE LEVELS IN BLOOD (IFNγ, TNFα, IL-10) AND INTERCELLULAR ADHESION MOLECULE (sICAM-1) IN PATIENTS WITH PNEUMONIA INFLUENZA A/H1N1

Abstract

Abstract. The changes of cytokine profile revealed in viral influenza-associated pneumonia (A/H1N1) were shown to exceed appropriate parameters for the cases of bacterial outpatient pneumonia. The most expressed hyperproduction of proinflammatory cytokines (IFNγ, TNFα), and a marker of pathological endothelial activation (sICAM-1) was registered in more severe cases, including those with ALI/ARDS, thus confirming a prognostic value of these parameters. An increased level of IL-10 and decreased IFNγ and TNFα concentrations in the non-severe flu-like pneumonia are indicative for a more balanced immune response. Increased IFNγ concentrations at six months after influenza-associated pneumonia (A/H1N1) may be caused by prolonged use of interferon inducers, as well as persistent antiviral immunity.

Keywords

• influenza a (h1n1)
• pneumonia
• cytokines
• intercellular adhesion molecules