Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam; Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
Nhu Da Le
Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
Thi Hong Anh Nguyen
Center for High Technology Transfer Research and Development, VAST, Hanoi, Vietnam
Hoang Giang Do
Center for High Technology Transfer Research and Development, VAST, Hanoi, Vietnam
Thi Luyen Nguyen
Center for High Technology Transfer Research and Development, VAST, Hanoi, Vietnam
Ngoc Minh Truong
Center for High Technology Transfer Research and Development, VAST, Hanoi, Vietnam
Thi Thuy Duong
Institute of Science and Technology for Energy and Environment, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam; Center for High Technology Transfer Research and Development, VAST, Hanoi, Vietnam
Furan derivatives are recognized for their diverse biological activities, particularly their antimicrobial properties. In this study, three new furan derivatives were isolated from acid-treated Chrysanthemum indicum flowers. The structures were elucidated using spectroscopic techniques and identified as methyl (E)-3-((5-(methoxymethyl)furan-2-yl)methylene)-4-oxopentanoate (1), methyl (Z)-3-((5-(methoxymethyl)furan-2-yl)methylene)-4-oxopentanoate (2), and methyl (E)-3-(furan-2-ylmethylene)-4-oxopentanoate (3). These compounds were evaluated for antibacterial activity against Vibrio spp. and Microcystis aeruginosa. Compound 3 showed the highest inhibition (63.5%) against M. aeruginosa at 50 μg/mL, with compounds 1 and 2 demonstrating lower activities (36.1% and 58.3%, respectively). The structural difference between compounds 1 and 2, limited to the double bond geometry, likely contributes to their varying efficacies. These findings indicate that furan derivatives from C. indicum could be promising candidates for antimicrobial applications, particularly in aquaculture.
