BA.2 and BA.5 omicron differ immunologically from both BA.1 omicron and pre-omicron variants

Annika Rössler; Antonia Netzl; Ludwig Knabl; Helena Schäfer; Samuel H. Wilks; David Bante; Barbara Falkensammer; Wegene Borena; Dorothee von Laer; Derek J. Smith; Janine Kimpel

doi:10.1038/s41467-022-35312-3

Nature Communications (Dec 2022)

BA.2 and BA.5 omicron differ immunologically from both BA.1 omicron and pre-omicron variants

Annika Rössler,
Antonia Netzl,
Ludwig Knabl,
Helena Schäfer,
Samuel H. Wilks,
David Bante,
Barbara Falkensammer,
Wegene Borena,
Dorothee von Laer,
Derek J. Smith,
Janine Kimpel

Affiliations

Annika Rössler: Institute of Virology, Department of Hygiene, Microbiology and Public Health, Medical University of Innsbruck
Antonia Netzl: University of Cambridge, Center for Pathogen Evolution, Department of Zoology
Ludwig Knabl: Tyrolpath Obrist Brunhuber GmbH
Helena Schäfer: Institute of Virology, Department of Hygiene, Microbiology and Public Health, Medical University of Innsbruck
Samuel H. Wilks: University of Cambridge, Center for Pathogen Evolution, Department of Zoology
David Bante: Institute of Virology, Department of Hygiene, Microbiology and Public Health, Medical University of Innsbruck
Barbara Falkensammer: Institute of Virology, Department of Hygiene, Microbiology and Public Health, Medical University of Innsbruck
Wegene Borena: Institute of Virology, Department of Hygiene, Microbiology and Public Health, Medical University of Innsbruck
Dorothee von Laer: Institute of Virology, Department of Hygiene, Microbiology and Public Health, Medical University of Innsbruck
Derek J. Smith: University of Cambridge, Center for Pathogen Evolution, Department of Zoology
Janine Kimpel: Institute of Virology, Department of Hygiene, Microbiology and Public Health, Medical University of Innsbruck

DOI: https://doi.org/10.1038/s41467-022-35312-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 9

Abstract

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SARS-CoV-2 omicron variant BA.1 has shown increased transmissibility and immune escape, relative to previous SARS-CoV-2 variants. In this study, authors utilise antigenic cartography to characterise the neutralisation profiles of omicron sub-lineages, BA.2 and BA.5, in comparison to BA.1 and pre-omicron variants.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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