First report of hepatobiliary Mycobacterium avium infection developing obstructive jaundice in a patient with neutralizing anti–interferon-gamma autoantibodies

H. Namkoong; T. Asakura; M. Ishii; S. Yoda; K. Masaki; T. Sakagami; E. Iwasaki; Y. Yamagishi; T. Kanai; T. Betsuyaku; N. Hasegawa

New Microbes and New Infections (Jan 2019)

First report of hepatobiliary Mycobacterium avium infection developing obstructive jaundice in a patient with neutralizing anti–interferon-gamma autoantibodies

H. Namkoong,
T. Asakura,
M. Ishii,
S. Yoda,
K. Masaki,
T. Sakagami,
E. Iwasaki,
Y. Yamagishi,
T. Kanai,
T. Betsuyaku,
N. Hasegawa

Affiliations

H. Namkoong: Keio University School of Medicine, Tokyo, Japan; Eiju General Hospital, Tokyo, Japan
T. Asakura: Keio University School of Medicine, Tokyo, Japan
M. Ishii: Keio University School of Medicine, Tokyo, Japan
S. Yoda: JCHO Saitama Medical Center, Saitama, Japan
K. Masaki: Keio University School of Medicine, Tokyo, Japan
T. Sakagami: Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
E. Iwasaki: Keio University School of Medicine, Tokyo, Japan
Y. Yamagishi: Keio University School of Medicine, Tokyo, Japan
T. Kanai: Keio University School of Medicine, Tokyo, Japan
T. Betsuyaku: Keio University School of Medicine, Tokyo, Japan
N. Hasegawa: Keio University School of Medicine, Tokyo, Japan; Corresponding author: N. Hasegawa, Center for Infectious Diseases and Infection Control, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Journal volume & issue: Vol. 27
pp. 4 – 6

Abstract

Read online

This study describes a patient who experienced hepatobiliary Mycobacterium avium infection associated with neutralizing anti–interferon gamma (IFN-γ) autoantibodies during treatment for disseminated M. avium disease. Hepatobiliary M. avium infection should be considered in jaundiced patients with neutralizing anti–IFN-γ autoantibodies, including those receiving antimycobacterial therapy for disseminated M. avium disease. Keywords: Anti–interferon gamma (IFN-γ) autoantibody, disseminated Mycobacterium aviumcomplex infection, hepatobiliary infection, jaundice, Mycobacterium aviumcomplex (MAC)

Published in New Microbes and New Infections

ISSN: 2052-2975 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: https://www.sciencedirect.com/journal/new-microbes-and-new-infections

About the journal