Current Oncology (Aug 2024)

Feasibility of a Novel 3D Ultrasound Imaging Technique for Intraoperative Margin Assessment during Tongue Cancer Surgery

  • Fatemeh Makouei,
  • Theresa Dahl Frehr,
  • Tina Klitmøller Agander,
  • Giedrius Lelkaitis,
  • Mette Hyldig Dal,
  • Mikkel Kaltoft,
  • Lisa Orloff,
  • Merry Sebelik,
  • Morten Bo Søndergaard Svendsen,
  • Irene Wessel,
  • Tobias Todsen

DOI
https://doi.org/10.3390/curroncol31080330
Journal volume & issue
Vol. 31, no. 8
pp. 4414 – 4431

Abstract

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Squamous cell carcinoma (SCC) of the tongue is the most prevalent form of oral cavity cancer, with surgical intervention as the preferred method of treatment. Achieving negative or free resection margins of at least 5 mm is associated with improved local control and prolonged survival. Nonetheless, margins that are close (1–5 mm) or positive (less than 1 mm) are often observed in practice, especially for the deep margins. Ultrasound is a promising tool for assessing the depth of invasion, providing non-invasive, real-time imaging for accurate evaluation. We conducted a clinical trial using a novel portable 3D ultrasound imaging technique to assess ex vivo surgical margin assessment in the operating room. During the operation, resected surgical specimens underwent 3D ultrasound scanning. Four head and neck surgeons measured the surgical margins (deep, medial, and lateral) and tumor area on the 3D ultrasound volume. These results were then compared with the histopathology findings evaluated by two head and neck pathologists. Six patients diagnosed with tongue SCC (three T1 stage and three T2 stage) were enrolled for a consecutive cohort. The margin status was correctly categorized as free by 3D ultrasound in five cases, and one case with a “free” margin status was incorrectly categorized by 3D ultrasound as a “close” margin. The Pearson correlation between ultrasound and histopathology was 0.7 (p p p < 0.05) for deep, medial, and lateral margin measurements, respectively. Bland–Altman analysis compared the mean difference and 95% limits of agreement (LOA) for deep margin measurement by 3D ultrasound and histopathology, with a mean difference of 0.7 mm (SD 1.15 mm). This clinical trial found that 3D ultrasound is accurate in deep margin measurements. The implementation of intraoperative 3D ultrasound imaging of surgical specimens may improve the number of free margins after tongue cancer treatment.

Keywords