Placental Protein 13 and Syncytiotrophoblast Basement Membrane Ultrastructures in Preeclampsia
Peby Maulina Lestari,
Noroyono Wibowo,
Damar Prasmusinto,
Muhammad Yamin,
Nuryati Chairani Siregar,
Joedo Prihartono,
Ina Susianti Timan,
Johanes C. Mose,
Iche Andriyani Liberty,
Cindy Kesty,
Bella Stevanny
Affiliations
Peby Maulina Lestari
Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin General Hospital, Faculty of Medicine, Universitas Sriwijaya, Palembang 30114, Indonesia
Noroyono Wibowo
Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
Damar Prasmusinto
Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
Muhammad Yamin
Department of Cardiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
Nuryati Chairani Siregar
Department of Anatomical Pathology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
Joedo Prihartono
Department of Community Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
Ina Susianti Timan
Departement of Clinical Pathology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
Johanes C. Mose
Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung 45363, Indonesia
Iche Andriyani Liberty
Department of Public Health and Community Medicine, Faculty of Medicine, Universitas Sriwijaya, Palembang 30114, Indonesia
Cindy Kesty
Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin General Hospital, Faculty of Medicine, Universitas Sriwijaya, Palembang 30114, Indonesia
Bella Stevanny
Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin General Hospital, Faculty of Medicine, Universitas Sriwijaya, Palembang 30114, Indonesia
Background and Objectives: Preeclampsia has been linked to an inflammatory response that may be brought on by endothelial cell dysfunction. This paper investigates the pathomechanism of syncytiotrophoblast basement membrane (STBM) damage and Placental Protein 13 (PP13) release, which may have a role in systemic endothelial dysfunction in preeclampsia. Materials and Methods: This comparative cross-sectional study involves 54 preeclampsia patients (27 early-onset preeclampsia and 27 late-onset preeclampsia) and 27 pregnant women with normal blood pressure. An enzyme-linked immunosorbent assay was performed to evaluate maternal blood levels of PP13. Following birth, a portion of the placenta was collected for transmission electron microscope (TEM) and immunohistochemical (IHC) analysis. The data were analyzed using STATA version 15. Results: PP13 expression in the placental syncytiotrophoblast was significantly lower in the early-onset preeclampsia, compared to late-onset preeclampsia and normotensive pregnancy, group (p Conclusions: PP13 and STBM damage may play a role in systemic endothelial dysfunction in preeclampsia.
