Nature Communications (Mar 2017)

Theory of optimal balance predicts and explains the amplitude and decay time of synaptic inhibition

  • Jaekyung K. Kim,
  • Christopher D. Fiorillo

DOI
https://doi.org/10.1038/ncomms14566
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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Inhibition and excitation are counterbalanced at synapses, but the conditions that constitute optimal balance are not known. Here the authors show through modelling that the properties of synaptic inhibition are fine-tuned to maintain an optimal balance in which peak excitation reaches precisely to spike threshold.