Correlation between Subfascial Fat Loss and Decrease in Serum Insulin Levels

Abstract

Objective: To determine the association between reductions of fat from subcutaneous, intermuscular and subfascial compartment at thighs and improvement of serum insulin level. Methods: A longitudinal, clinical intervention study of restricted energy with exercise was performed in 20 healthy, overweight teenagers (age: 10-15 y, BMI: 26-40 kg/m2). Fat distribution parameter (by dual-energy X-ray absorptiometry and computerized axial tomography at thigh), serum insulin, body weight were assessed at baseline and after 4 weeks. Results: There are significant reductions in bodyweight, BMI, serum insulin, FGIR subfascial fat and intermuscular fat after 4 weeks. Loss of subfascial fat at thighs is significantly associated with decreasing levels of serum insulin in those who have initially abnormal high levels. Conclusion: Losses of subfascial fat at thighs is associated with improvement of insulin levels in obese teenagers who are on 4 weeks of dietary restriction and moderate exercise.Â

Keywords

• Computed tomography
• obese teenager
• subfascial fat
• serum insulin
• weight-reduction program