Association between conventional or blue-light-filtering intraocular lenses and survival in bilateral cataract surgery patients
John E. Griepentrog,
Xianghong Zhang,
Oscar C. Marroquin,
Michael B. Garver,
AnnaElaine L. Rosengart,
Joyce Chung-Chou Chang,
Hamed Esfandiari,
Nils A. Loewen,
Matthew R. Rosengart
Affiliations
John E. Griepentrog
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
Xianghong Zhang
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
Oscar C. Marroquin
Department of Clinical Analytics, University of Pittsburgh Medical Center Health Services Division, Pittsburgh, PA 15213, USA
Michael B. Garver
Department of Clinical Analytics, University of Pittsburgh Medical Center Health Services Division, Pittsburgh, PA 15213, USA
AnnaElaine L. Rosengart
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
Joyce Chung-Chou Chang
Department of Medicine, Biostatistics, and Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA 15213, USA
Hamed Esfandiari
Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL 602080, USA; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Nils A. Loewen
Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Ophthalmology, University of Würzburg, Würzburg 97070, Germany
Matthew R. Rosengart
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA; Corresponding author
Summary: Circadian rhythms regulate adaptive alterations in mammalian physiology and are maximally entrained by the short wavelength blue spectrum; cataracts block the transmission of light, particularly blue light. Cataract surgery is performed with two types of intraocular lenses (IOL): (1) conventional IOL that transmit the entire visible spectrum and (2) blue-light-filtering (BF) IOL that block the short wavelength blue spectrum. We hypothesized that the transmission properties of IOL are associated with long-term survival. This retrospective cohort study of a 15-hospital healthcare system identified 9,108 participants who underwent bilateral cataract surgery; 3,087 were implanted with conventional IOL and 6,021 received BF-IOL. Multivariable Cox proportional hazards models that included several a priori determined subgroup and sensitivity analyses yielded estimates supporting that conventional IOL compared with BF-IOL may be associated with significantly reduced risk of long-term death. Confirming these differences and identifying any potential causal mechanisms await the conduct of appropriately controlled prospective translational trials.
