Nature Communications (Aug 2016)

β-Catenin C-terminal signals suppress p53 and are essential for artery formation

  • Dario F. Riascos-Bernal,
  • Prameladevi Chinnasamy,
  • Longyue (Lily) Cao,
  • Charlene M. Dunaway,
  • Tomas Valenta,
  • Konrad Basler,
  • Nicholas E. S. Sibinga

DOI
https://doi.org/10.1038/ncomms12389
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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How p53 is restrained in arterial maturation during embryonic development is unclear. Here, the authors show that β-catenin C-terminal interactions inhibit CREB binding protein-mediated acetylation and activation of p53 in smooth muscle cells, and that this function is essential for artery formation.