Nature Communications (Aug 2016)
β-Catenin C-terminal signals suppress p53 and are essential for artery formation
Abstract
How p53 is restrained in arterial maturation during embryonic development is unclear. Here, the authors show that β-catenin C-terminal interactions inhibit CREB binding protein-mediated acetylation and activation of p53 in smooth muscle cells, and that this function is essential for artery formation.