Nature Communications (Oct 2021)
A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase
- Jessie MacAlpine,
- Martin Daniel-Ivad,
- Zhongle Liu,
- Junko Yano,
- Nicole M. Revie,
- Robert T. Todd,
- Peter J. Stogios,
- Hiram Sanchez,
- Teresa R. O’Meara,
- Thomas A. Tompkins,
- Alexei Savchenko,
- Anna Selmecki,
- Amanda O. Veri,
- David R. Andes,
- Paul L. Fidel,
- Nicole Robbins,
- Justin Nodwell,
- Luke Whitesell,
- Leah E. Cowen
Affiliations
- Jessie MacAlpine
- Department of Molecular Genetics, University of Toronto
- Martin Daniel-Ivad
- Department of Biochemistry, University of Toronto
- Zhongle Liu
- Department of Molecular Genetics, University of Toronto
- Junko Yano
- Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry
- Nicole M. Revie
- Department of Molecular Genetics, University of Toronto
- Robert T. Todd
- Department of Microbiology and Immunology, University of Minnesota Medical School
- Peter J. Stogios
- BioZone, Department of Chemical Engineering and Applied Chemistry, University of Toronto
- Hiram Sanchez
- Department of Medicine, University of Wisconsin School of Medicine and Public Health
- Teresa R. O’Meara
- Department of Microbiology and Immunology, University of Michigan Medical School
- Thomas A. Tompkins
- Rosell Institute for Microbiome and Probiotics, 6100 Avenue Royalmount
- Alexei Savchenko
- BioZone, Department of Chemical Engineering and Applied Chemistry, University of Toronto
- Anna Selmecki
- Department of Microbiology and Immunology, University of Minnesota Medical School
- Amanda O. Veri
- Department of Molecular Genetics, University of Toronto
- David R. Andes
- Department of Medicine, University of Wisconsin School of Medicine and Public Health
- Paul L. Fidel
- Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry
- Nicole Robbins
- Department of Molecular Genetics, University of Toronto
- Justin Nodwell
- Department of Biochemistry, University of Toronto
- Luke Whitesell
- Department of Molecular Genetics, University of Toronto
- Leah E. Cowen
- Department of Molecular Genetics, University of Toronto
- DOI
- https://doi.org/10.1038/s41467-021-26390-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Alterations of the mucosal microbiota, including Lactobacillus bacteria, are associated with infections caused by the fungus Candida albicans. Here, MacAlpine et al. show that some Lactobacillus strains produce a small molecule that blocks C. albicans filamentation and biofilm formation, and thus virulence, through inhibition of a fungal kinase.
