Nature Communications (May 2022)
DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases
- Matthias Wielscher,
- Pooja R. Mandaviya,
- Brigitte Kuehnel,
- Roby Joehanes,
- Rima Mustafa,
- Oliver Robinson,
- Yan Zhang,
- Barbara Bodinier,
- Esther Walton,
- Pashupati P. Mishra,
- Pascal Schlosser,
- Rory Wilson,
- Pei-Chien Tsai,
- Saranya Palaniswamy,
- Riccardo E. Marioni,
- Giovanni Fiorito,
- Giovanni Cugliari,
- Ville Karhunen,
- Mohsen Ghanbari,
- Bruce M. Psaty,
- Marie Loh,
- Joshua C. Bis,
- Benjamin Lehne,
- Nona Sotoodehnia,
- Ian J. Deary,
- Marc Chadeau-Hyam,
- Jennifer A. Brody,
- Alexia Cardona,
- Elizabeth Selvin,
- Alicia K. Smith,
- Andrew H. Miller,
- Mylin A. Torres,
- Eirini Marouli,
- Xin Gào,
- Joyce B. J. van Meurs,
- Johanna Graf-Schindler,
- Wolfgang Rathmann,
- Wolfgang Koenig,
- Annette Peters,
- Wolfgang Weninger,
- Matthias Farlik,
- Tao Zhang,
- Wei Chen,
- Yujing Xia,
- Alexander Teumer,
- Matthias Nauck,
- Hans J. Grabe,
- Macus Doerr,
- Terho Lehtimäki,
- Weihua Guan,
- Lili Milani,
- Toshiko Tanaka,
- Krista Fisher,
- Lindsay L. Waite,
- Silva Kasela,
- Paolo Vineis,
- Niek Verweij,
- Pim van der Harst,
- Licia Iacoviello,
- Carlotta Sacerdote,
- Salvatore Panico,
- Vittorio Krogh,
- Rosario Tumino,
- Evangelia Tzala,
- Giuseppe Matullo,
- Mikko A. Hurme,
- Olli T. Raitakari,
- Elena Colicino,
- Andrea A. Baccarelli,
- Mika Kähönen,
- Karl-Heinz Herzig,
- Shengxu Li,
- BIOS consortium,
- Karen N. Conneely,
- Jaspal S. Kooner,
- Anna Köttgen,
- Bastiaan T. Heijmans,
- Panos Deloukas,
- Caroline Relton,
- Ken K. Ong,
- Jordana T. Bell,
- Eric Boerwinkle,
- Paul Elliott,
- Hermann Brenner,
- Marian Beekman,
- Daniel Levy,
- Melanie Waldenberger,
- John C. Chambers,
- Abbas Dehghan,
- Marjo-Riitta Järvelin
Affiliations
- Matthias Wielscher
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Pooja R. Mandaviya
- Department of Internal Medicine, Erasmus University Medical Center
- Brigitte Kuehnel
- Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Roby Joehanes
- Framingham Heart Study
- Rima Mustafa
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Oliver Robinson
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Yan Zhang
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center
- Barbara Bodinier
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Esther Walton
- Department of Psychology, University of Bath
- Pashupati P. Mishra
- Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University
- Pascal Schlosser
- Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg
- Rory Wilson
- Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Pei-Chien Tsai
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Saranya Palaniswamy
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Riccardo E. Marioni
- Centre for Genomic and Experimental Medicine, University of Edinburgh
- Giovanni Fiorito
- Laboratory of Biostatistics, Department of Biomedical Sciences, University of Sassari
- Giovanni Cugliari
- Fondazione IRCCS Istituto Nazionale dei Tumori
- Ville Karhunen
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Mohsen Ghanbari
- Department of Epidemiology, Erasmus MC University Medical Center
- Bruce M. Psaty
- Cardiovacular Health Research Unit, Department of Medicine, University of Washington
- Marie Loh
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Joshua C. Bis
- Cardiovascular Health Research Unit, Division of Cardiology, University of Washington
- Benjamin Lehne
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Nona Sotoodehnia
- Cardiovascular Health Research Unit, Division of Cardiology, University of Washington
- Ian J. Deary
- Lothian Birth Cohorts, Department of Psychology, University of Edinburgh
- Marc Chadeau-Hyam
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Jennifer A. Brody
- Cardiovascular Health Research Unit, Division of Cardiology, University of Washington
- Alexia Cardona
- MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge
- Elizabeth Selvin
- Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Alicia K. Smith
- Departments of Gynecology and Obstetrics & Psychiatry and Behavioral Science, Emory University School of Medicine
- Andrew H. Miller
- Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine
- Mylin A. Torres
- Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine
- Eirini Marouli
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Xin Gào
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center
- Joyce B. J. van Meurs
- Department of Internal Medicine, Erasmus University Medical Center
- Johanna Graf-Schindler
- Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Wolfgang Rathmann
- Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Resesarch at Heinrich Heine University Düsseldorf
- Wolfgang Koenig
- Deutsches Herzzentrum München, Technische Universität München
- Annette Peters
- Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Wolfgang Weninger
- Department of Dermatology, Medical University of Vienna
- Matthias Farlik
- Department of Dermatology, Medical University of Vienna
- Tao Zhang
- Deptarment of Biostatistics, School of Public Health, Shandong University
- Wei Chen
- Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University
- Yujing Xia
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Alexander Teumer
- Institute for Community Medicine, University Medicine Greifswald
- Matthias Nauck
- DZHK (German Center for Cardiovascular Research), Partner Site Greifswald
- Hans J. Grabe
- Department of Psychiatry and Psychotherapy, University Medicine Greifswald
- Macus Doerr
- DZHK (German Center for Cardiovascular Research), Partner Site Greifswald
- Terho Lehtimäki
- Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University
- Weihua Guan
- Division of Biostatistics, School of Public Health, University of Minnesota
- Lili Milani
- Estonian Genome Centre, Institute of Genomics, University of Tartu
- Toshiko Tanaka
- Translational Gerontology Branch, Biomedical Research Center, National Institute on Aging, National Institutes of Health
- Krista Fisher
- Estonian Genome Centre, Institute of Genomics, University of Tartu
- Lindsay L. Waite
- HudsonAlpha Institute for Biotechnology
- Silva Kasela
- Estonian Genome Centre, Institute of Genomics, University of Tartu
- Paolo Vineis
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Niek Verweij
- Department of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1
- Pim van der Harst
- Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht
- Licia Iacoviello
- Department of Epidemiology and Prevention, IRCCS NEUROMED
- Carlotta Sacerdote
- Unit of Cancer Epidemiology, Citta’ della Salute e della Scienza Hospital and Centre for Cancer Prevention
- Salvatore Panico
- Dipartimento di Medicina Clinica e Chirurgia Federico II University
- Vittorio Krogh
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori
- Rosario Tumino
- Cancer Registry and Histopathology Department, “Civic - MPP Arezzo” Hospital, ASP Ragusa
- Evangelia Tzala
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Giuseppe Matullo
- Department of Medical Sciences, University of Turin
- Mikko A. Hurme
- Faculty of Medicine and Health Technology, Tampere University
- Olli T. Raitakari
- Research centre of Applied and Preventive Cardiovascular Medicine, University of Turku
- Elena Colicino
- Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai
- Andrea A. Baccarelli
- Laboratory of Environmental Epigenetics, Departments of Environmental Health Sciences and Epidemiology, Columbia University Mailman School of Public Health
- Mika Kähönen
- Finnish Cardiovascular Research Centre, Faculty of Medicine and Health Technology, Tampere University
- Karl-Heinz Herzig
- Research Unit of Biomedicine, Medical Research Center, Faculty of Medicine, University of Oulu, and Oulu University Hospital
- Shengxu Li
- Children’s Minnesota Research Institute, Children’s Minnesota
- BIOS consortium
- Karen N. Conneely
- Department of Human Genetics, Emory University School of Medicine
- Jaspal S. Kooner
- National Heart and Lung Institute, Imperial College London
- Anna Köttgen
- Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg
- Bastiaan T. Heijmans
- Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center
- Panos Deloukas
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Caroline Relton
- Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol
- Ken K. Ong
- MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge
- Jordana T. Bell
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Eric Boerwinkle
- Human Genetics Center, University of Texas Health Science Center at Houston
- Paul Elliott
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Hermann Brenner
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center
- Marian Beekman
- Department of Medical Statistics and Bioinformatics, Leiden University Medical Center
- Daniel Levy
- Framingham Heart Study
- Melanie Waldenberger
- Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- John C. Chambers
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Abbas Dehghan
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Marjo-Riitta Järvelin
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- DOI
- https://doi.org/10.1038/s41467-022-29792-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Chronic inflammation, marked by C-reactive protein, has been associated with changes in methylation, but the causal relationship is unclear. Here, the authors perform a Epigenome-wide association meta-analysis for C-reactive protein levels and find that these methylation changes are likely the consequence of inflammation and could contribute to disease.
