Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject ‘cold’ tumors

• Laetitia Fend,
• Eric Quemeneur,
• Monika Semmrich,
• Jean-Baptiste Marchand,
• Matilda Rehn,
• Nathalie Silvestre,
• Linda Mårtensson,
• Johann Foloppe,
• Ingrid Teige,
• Björn Frendeus,
• Petra Holmkvist,
• Carolin Svensson,
• Christelle Remy,
• Patricia Kleinpeter,
• Jules Deforges,
• Fred Junghus,
• Kirstie L Cleary,
• Mimoza Bodén

Affiliations

Laetitia Fend

Aff1 grid.420228.e0000 0004 0638 2273Transgene France

Eric Quemeneur

Aff4 grid.420228.e0000000406382273Transgene SA Parc d’Innovation, CS80166 67405 Illkirch-Graffenstaden Cedex France

Monika Semmrich

Preclinical Research, BioInvent International AB, Lund, Sweden

Jean-Baptiste Marchand

2Transgene SA, Illkirch Graffenstaden, France

Matilda Rehn

1BioInvent International AB, Lund, Sweden

Nathalie Silvestre

2Transgene SA, Illkirch Graffenstaden, France

Linda Mårtensson

Preclinical Research, BioInvent International AB, Lund, Sweden

Johann Foloppe

2Transgene SA, Illkirch Graffenstaden, France

Ingrid Teige

Preclinical Research, BioInvent International AB, Lund, Sweden

Björn Frendeus

1BioInvent International AB, Lund, Sweden

Petra Holmkvist

BiInvent International, Lund, Sweden

Carolin Svensson

BiInvent International, Lund, Sweden

Christelle Remy

Department of Research, Transgene SA, Illkirch-Graffenstaden, France

Patricia Kleinpeter

Department of Research, Transgene SA, Illkirch-Graffenstaden, France

Jules Deforges

Department of Research, Transgene SA, Illkirch-Graffenstaden, France

Fred Junghus

Department of Research, BioInvent International AB, Lund, Sweden

Kirstie L Cleary

Antibody and Vaccine Group, Centre for Cancer Immunology, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK

Mimoza Bodén

Department of Research, BioInvent International AB, Lund, Sweden