aP2 Protein Expression as a Diagnostic Marker in Soft Tissue Tumours

T. T. Yang; A. C. C. Reed; N. A. Athanasou

doi:10.1080/13577140120048593

Sarcoma (Jan 2001)

aP2 Protein Expression as a Diagnostic Marker in Soft Tissue Tumours

T. T. Yang,
A. C. C. Reed,
N. A. Athanasou

Affiliations

T. T. Yang: Department of Pathology, Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, Oxford OX3 7LD, UK
A. C. C. Reed: Department of Pathology, Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, Oxford OX3 7LD, UK
N. A. Athanasou: Department of Pathology, Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, Oxford OX3 7LD, UK

DOI: https://doi.org/10.1080/13577140120048593
Journal volume & issue: Vol. 5, no. 3
pp. 139 – 142

Abstract

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Purpose/Methods: The aP2 gene product (aP2 protein) is known to be expressed by preadipocytes and other immature fat cells in vitro. A mouse monoclonal antibody raised against an 18 amino acid segment of the aP2 protein was found to react with lipoblasts and fetal fat cells in paraffin sections of soft tissue tumours of adipose differentiation. In this immunohistochemical study, we have further examined the diagnostic utility of aP2 expression in distinguishing tumours of adipose differentiation from other benign and malignant soft tissue tumours.

Published in Sarcoma

ISSN: 1357-714X (Print); 1369-1643 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://onlinelibrary.wiley.com/journal/5805

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