Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1

Shigeru Matsumura; Tomoko Kojidani; Yuji Kamioka; Seiichi Uchida; Tokuko Haraguchi; Akatsuki Kimura; Fumiko Toyoshima

doi:10.1038/ncomms11858

Nature Communications (Jun 2016)

Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1

Shigeru Matsumura,
Tomoko Kojidani,
Yuji Kamioka,
Seiichi Uchida,
Tokuko Haraguchi,
Akatsuki Kimura,
Fumiko Toyoshima

Affiliations

Shigeru Matsumura: Department of Cell Biology, Institute for Virus Research, Kyoto University, Sakyo-ku
Tomoko Kojidani: Advanced ICT Research Institute Kobe, National Institute of Information and Communication Technology, Nishi-ku
Yuji Kamioka: Department of Pathology and Biology of Diseases, Kyoto University
Seiichi Uchida: Faculty of Information Science and Electrical Engineering, Kyushu University, Nishi-ku
Tokuko Haraguchi: Advanced ICT Research Institute Kobe, National Institute of Information and Communication Technology, Nishi-ku
Akatsuki Kimura: Cell Architecture Laboratory, Structural Biology Center, National Institute of Genetics
Fumiko Toyoshima: Department of Cell Biology, Institute for Virus Research, Kyoto University, Sakyo-ku

DOI: https://doi.org/10.1038/ncomms11858
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Studies imply that cell adhesion geometry during interphase dictates the orientation of the cell division axis. Here the authors show that accumulation of caveolin-1 to rapidly retracting regions during cell rounding sets the spindle orientation by recruiting Gαi1-LGN-NuMA to the cortex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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