Mechanisms of Tripterygium wilfordii Hook F on treating rheumatoid arthritis explored by network pharmacology analysis and molecular docking

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory and disabling disease that imposes significant economic and social costs. Tripterygium wilfordii Hook F (TwHF) has a long history of use in traditional Chinese medicine for treating joint disorders, and it has been shown to be cost-effective in treating RA, but its exact mechanism is unknown.

Keywords

• network pharmacology
• rheumatoid arthritis
• tripterygium wilfordii hook f
• inflammatory cytokine
• chemotaxis
• angiogenesis
• molecular docking