Arquivos de Neuro-Psiquiatria ()

Motor and non-motor wearing-off and its impact in the quality of life of patients with Parkinson's disease

  • Mayela Rodríguez-Violante,
  • Natalia Ospina-García,
  • Ned Merari Dávila-Avila,
  • Diego Cruz-Fino,
  • Alejandra de la Cruz-Landero,
  • Amin Cervantes-Arriaga

DOI
https://doi.org/10.1590/0004-282x20180074
Journal volume & issue
Vol. 76, no. 8
pp. 517 – 521

Abstract

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ABSTRACT The wearing-off phenomenon is common in patients with Parkinson's disease. Motor and non-motor symptoms can fluctuate in relation to the “on/off” periods. Objective: To assess the impact of motor and non-motor wearing-off on activities of daily living and quality of life of patients with PD. Methods: A cross-sectional study was carried out. All patients were evaluated using the Movement Disorders Society Unified Parkinson's Disease Rating Scale. Wearing-off was assessed using the Wearing-Off Questionnaire-19, and quality of life was assessed using the Parkinson's Disease Questionnaire-8. Results: A total of 271 patients were included; 73.4% had wearing-off; 46.8% had both motor and non-motor fluctuations. Patients with both motor and non-motor wearing-off had a worst quality of life compared with those with only motor fluctuations (p = 0.047). Conclusions: Motor and non-motor fluctuations have an impact on activities of daily living and quality of life. Non-motor wearing-off may have a higher impact.

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