Cancer Management and Research (Aug 2023)
The Progress of Platelets in Breast Cancer
Abstract
Luchang Wang,1,2 Kaijiong Zhang,3 Jia Feng,1 Dongsheng Wang,3 Jinbo Liu1 1Department of Laboratory Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, People’s Republic of China; 2Department of Clinical Laboratory, Chengdu Second People’s Hospital, Chengdu, 610017, People’s Republic of China; 3Department of Clinical Laboratory, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610041, People’s Republic of ChinaCorrespondence: Jinbo Liu, Department of Laboratory Medicine, Affiliated Hospital of Southwest Medical University, No. 5, Section 3, Zhongshan Road, Jiangyang District, Luzhou, Sichuan Province, 646000, People’s Republic of China, Tel +86 0830 3165120, Email [email protected]: Breast cancer is the most common female cancer and the sixth leading cause of death, seriously affecting the quality of life of women. Platelets, one of the fragments derived from megakaryocytes, are being increasingly investigated by tumor researchers because of their anticoagulant function. According to relevant studies, platelets, as the key source of circulating angiogenesis-related factors, can regulate tumor angiogenesis and vascular integrity, and they can also affect the tumor microenvironment, thereby facilitating the proliferation and differentiation of tumor cells. By covering or transferring normal MHC I molecules to tumor cells, platelets can protect tumor cells from being killed by the immune system and facilitate tumor cell metastasis. However, details on the mechanisms involved have remained elusive. This paper reviews and analyzes studies of the role of platelets in tumorigenesis, tumor cell proliferation, tumor metastasis, and cancer treatment to provide readers with a better understanding of the relevant studies.Keywords: breast cancer, platelets, angiogenesis, proliferation, metastasis
