Unmixing for ultra-high-plex fluorescence imaging

Archibald Enninful; Alev Baysoy; Rong Fan

doi:10.1038/s41467-022-31110-z

Nature Communications (Jun 2022)

Unmixing for ultra-high-plex fluorescence imaging

Archibald Enninful,
Alev Baysoy,
Rong Fan

Affiliations

Archibald Enninful: Department of Biomedical Engineering, Yale University
Alev Baysoy: Department of Biomedical Engineering, Yale University
Rong Fan: Department of Biomedical Engineering, Yale University

DOI: https://doi.org/10.1038/s41467-022-31110-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 3

Abstract

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Writing in Nature communications, Seo and collaborators presented PICASSO as a method to achieve 15-color imaging of spatially overlapping proteins using no reference emission spectra in a single staining and imaging round. This accessible tool has the potential to be applied to diverse applications within the spatial biology field without neglecting accuracy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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