The еffects of low mineral content water on microbiota, metabolic, and oxidative stress parameters in patients with type 2 diabetes mellitus
Nikola Jovicic,
Marijana Andjic,
Jovana Novakovic,
Nevena Jeremic,
Vladimir Zivkovic,
Ivan Srejovic,
Dejan Stanojevic,
Petar Ristic,
Sergey Bolevich,
Vladimir Jakovljevic
Affiliations
Nikola Jovicic
Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Marijana Andjic
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders; Kragujevac, Serbia
Jovana Novakovic
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders; Kragujevac, Serbia
Nevena Jeremic
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders; Kragujevac, Serbia; 1st Moscow State Medical, University IM Sechenov, Moscow, Russia
Vladimir Zivkovic
Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders; Kragujevac, Serbia; Department of Pharmacology, Institute of Biodesign and Complex System Modelling, First Moscow State Medical University I.M. Sechenov, Moscow, Russia; Corresponding author. Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, P.O.Box 124, 34000 Kragujevac, Serbia.
Ivan Srejovic
Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders; Kragujevac, Serbia; Department of Pharmacology, Institute of Biodesign and Complex System Modelling, First Moscow State Medical University I.M. Sechenov, Moscow, Russia
Dejan Stanojevic
Special Hospital Merkur, Vrnjacka Banja, Serbia
Petar Ristic
Clinic of Endocrinology, Military Medical Academy, Belgrade, Serbia
Sergey Bolevich
Department of Human Pathology, 1st Moscow State Medical, University IM Sechenov, Moscow, Russia
Vladimir Jakovljevic
Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders; Kragujevac, Serbia; Department of Human Pathology, 1st Moscow State Medical, University IM Sechenov, Moscow, Russia; Corresponding author. Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, P.O.Box 124, 34000 Kragujevac, Serbia.
Although scientific evidence has shown that natural mineral waters have potential beneficial metabolic effects, there is still very scarce data on their influence on type 2 diabetes mellitus (T2DM). The study was designed to investigate the effects of low mineral water from the “Sneznik-1/79″ source in Serbia on microbiota, metabolic, and oxidative stress parameters in patients with T2DM. In total, 60 patients with confirmed T2DM were included in the study, and they consumed “Sneznik-1/79″ water for 28 days. To examine the positive effects of “Sneznik-1/79″ water, we compared the results before and after the four weeks of “Sneznik-1/79″ water intake. Standard biochemical analyses were carried out, such as glucose level, lipid profile, and stool tests. The blood samples were collected to evaluate the effects of “Sneznik-1/79″ water on the redox status. At the end of the monitoring period, the total cholesterol concentration significantly dropped compared to the initial value. A significant improvement in intestinal peristalsis was observed, which was reflected in the fact that after four weeks, all patients established regular, daily bowel movements. Moreover, consumption of “Sneznik-1/79″ water eliminated the appearance of dysbiosis in 50% of patients. Additionally, the antioxidant capacity was improved by increasing the concentration of superoxide dismutase and reduced glutathione. The result of our study pointed out that the intake of “Sneznik-1/79″ water could be a promising adjuvant therapy for improving intestinal peristalsis as well as reducing the appearance of dysbiosis in T2DM patients.
