Cu(II)-Catalyzed C-N Coupling of (Hetero)aryl Halides and <i>N</i>-Nucleophiles Promoted by <i>α</i>-Benzoin Oxime

Abstract

We first reported the new application of a translate metal chelating ligand α-benzoin oxime for improving Cu-catalyzed C-N coupling reactions. The system could catalyse coupling reactions of (hetero)aryl halides with a wide of nucleophiles (e.g., azoles, piperidine, pyrrolidine and amino acids) in moderate to excellent yields. The protocol allows rapid access to the most common scaffolds found in FDA-approved pharmaceuticals.

Keywords

• α-benzoin oxime
• copper catalyst
• (hetero)aryl halides
• <i>n</i>-nucleophiles
• c-n coupling