PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis

Jinxue He; Zhong Zhang; Meng Ouyang; Fan Yang; Hongbo Hao; Kristy L. Lamb; Jingyi Yang; Yuxin Yin; Wen H. Shen

doi:10.1038/ncomms12355

Nature Communications (Aug 2016)

PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis

Jinxue He,
Zhong Zhang,
Meng Ouyang,
Fan Yang,
Hongbo Hao,
Kristy L. Lamb,
Jingyi Yang,
Yuxin Yin,
Wen H. Shen

Affiliations

Jinxue He: Department of Radiation Oncology, Weill Medical College of Cornell University
Zhong Zhang: Department of Radiation Oncology, Weill Medical College of Cornell University
Meng Ouyang: Department of Radiation Oncology, Weill Medical College of Cornell University
Fan Yang: Department of Radiation Oncology, Weill Medical College of Cornell University
Hongbo Hao: Department of Radiation Oncology, Weill Medical College of Cornell University
Kristy L. Lamb: Department of Radiation Oncology, Weill Medical College of Cornell University
Jingyi Yang: Department of Radiation Oncology, Weill Medical College of Cornell University
Yuxin Yin: Department of Radiation Oncology, Weill Medical College of Cornell University
Wen H. Shen: Department of Radiation Oncology, Weill Medical College of Cornell University

DOI: https://doi.org/10.1038/ncomms12355
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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One of the cellular functions of the tumour suppressor PTEN is to maintain genome stability. Here, the authors show that PTEN depletion leads to mitotic spindle shortening and chromosome misalignment due to aberrant EG5 activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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