Evaluation of the Histomorphometric and Micromorphometric Performance of a Serum Albumin-Coated Bone Allograft Combined with A-PRF for Early and Conventional Healing Protocols after Maxillary Sinus Augmentation: A Randomized Clinical Trial
Bálint Trimmel,
Szabolcs Gyulai-Gaál,
Márton Kivovics,
Noémi Piroska Jákob,
Csaba Hegedűs,
Bence Tamás Szabó,
Csaba Dobó-Nagy,
György Szabó
Affiliations
Bálint Trimmel
Department of Oral Diagnostics, Faculty of Dentistry, Semmelweis University, Szentkirályi utca 40, 1088 Budapest, Hungary
Szabolcs Gyulai-Gaál
Department of Oral Diagnostics, Faculty of Dentistry, Semmelweis University, Szentkirályi utca 40, 1088 Budapest, Hungary
Márton Kivovics
Department of Community Dentistry, Faculty of Dentistry, Semmelweis University, Szentkirályi utca 40, 1088 Budapest, Hungary
Noémi Piroska Jákob
Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, 1085 Budapest, Hungary
Csaba Hegedűs
Department of Biomaterials and Prosthetic Dentistry, Faculty of Dentistry, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary
Bence Tamás Szabó
Department of Oral Diagnostics, Faculty of Dentistry, Semmelweis University, Szentkirályi utca 40, 1088 Budapest, Hungary
Csaba Dobó-Nagy
Department of Oral Diagnostics, Faculty of Dentistry, Semmelweis University, Szentkirályi utca 40, 1088 Budapest, Hungary
György Szabó
Department of Oro-Maxillofacial Surgery and Stomatology, Faculty of Dentistry, Semmelweis University, Mária utca 52, 1085 Budapest, Hungary
The aim of this study was to compare the microarchitecture of augmented bone following maxillary sinus augmentation (MSA) after healing periods of 3 (test) and 6 (control) months using the combination of advanced platelet-rich fibrin (A-PRF) and a serum albumin-coated bone allograft (SACBA). Twenty-six patients with 30 surgical sites who required two-stage MSA were enrolled and grafted with the combination of A-PRF and SACBAs. The surgical sites were randomly allocated to the test or control group. During implant site preparation, 17 bone core biopsy samples were collected from each study group for histological, histomorphometric and micromorphometric analysis. Resonance frequency analysis was performed at the time of implant placement and 6, 8, 10, and 12 weeks postoperatively. The percentage of newly formed bone was 44.89 ± 9.49% in the test group and 39.75 ± 8.15% in the control group (p = 0.100). The results of the µCT analysis showed no significant differences in morphometric parameters between the study groups. The implant stability quotient was not significantly different between the two groups at 10 and 12 weeks postoperatively. Based on these findings, the total treatment time may be reduced by 3 months with the use of A-PRF and SACBAs for two-stage MSA.
