Dynamic functional connectivity in verbal cognitive control and word reading
Kazuki Sakakura,
Matthew Brennan,
Masaki Sonoda,
Takumi Mitsuhashi,
Aimee F Luat,
Neena I Marupudi,
Sandeep Sood,
Eishi Asano
Affiliations
Kazuki Sakakura
Department of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, United States; Department of Neurosurgery, Rush University Medical Center, Chicago, IL 60612, United States; Department of Neurosurgery, University of Tsukuba, Tsukuba 3058575, Japan
Matthew Brennan
Wayne State University, School of Medicine, Detroit, MI 48202, United States
Masaki Sonoda
Department of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, United States; Department of Neurosurgery, Yokohama City University, Yokohama 2360004, Japan
Takumi Mitsuhashi
Department of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, United States; Department of Neurosurgery, Juntendo University, School of Medicine, Tokyo 1138421, Japan
Aimee F Luat
Department of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, United States; Department of Neurology, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, United States; Department of Pediatrics, Central Michigan University, Mt. Pleasant, MI 48858, United States
Neena I Marupudi
Department of Neurosurgery, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, United States
Sandeep Sood
Department of Neurosurgery, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, United States
Eishi Asano
Department of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, United States; Department of Neurology, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, United States; Department of Pediatrics, Central Michigan University, Mt. Pleasant, MI 48858, United States; Translational Neuroscience Program, Wayne State University, Detroit, MI 48201, United States; Corresponding author at: Division of Pediatric Neurology, Children's Hospital of Michigan, Wayne State University, 3901 Beaubien St., Detroit, MI 48201, United States.
Cognitive control processes enable the suppression of automatic behaviors and the initiation of appropriate responses. The Stroop color naming task serves as a benchmark paradigm for understanding the neurobiological model of verbal cognitive control. Previous research indicates a predominant engagement of the prefrontal and premotor cortex during the Stroop task compared to reading. We aim to further this understanding by creating a dynamic atlas of task-preferential modulations of functional connectivity through white matter. Patients undertook word-reading and Stroop tasks during intracranial EEG recording. We quantified task-related high-gamma amplitude modulations at 547 nonepileptic electrode sites, and a mixed model analysis identified regions and timeframes where these amplitudes differed between tasks. We then visualized white matter pathways with task-preferential functional connectivity enhancements at given moments. Word reading, compared to the Stroop task, exhibited enhanced functional connectivity in inter- and intra-hemispheric white matter pathways from the left occipital-temporal region 350–600 ms before response, including the posterior callosal fibers as well as the left vertical occipital, inferior longitudinal, inferior fronto-occipital, and arcuate fasciculi. The Stroop task showed enhanced functional connectivity in the pathways from the left middle-frontal pre-central gyri, involving the left frontal u-fibers and anterior callosal fibers. Automatic word reading largely utilizes the left occipital-temporal cortices and associated white matter tracts. Verbal cognitive control predominantly involves the left middle frontal and precentral gyri and its connected pathways. Our dynamic tractography atlases may serve as a novel resource providing insights into the unique neural dynamics and pathways of automatic reading and verbal cognitive control.
