Population-scale study of eRNA transcription reveals bipartite functional enhancer architecture

Katla Kristjánsdóttir; Alexis Dziubek; Hyun Min Kang; Hojoong Kwak

doi:10.1038/s41467-020-19829-z

Nature Communications (Nov 2020)

Population-scale study of eRNA transcription reveals bipartite functional enhancer architecture

Katla Kristjánsdóttir,
Alexis Dziubek,
Hyun Min Kang,
Hojoong Kwak

Affiliations

Katla Kristjánsdóttir: Department of Molecular Biology and Genetics, Cornell University
Alexis Dziubek: Department of Molecular Biology and Genetics, Cornell University
Hyun Min Kang: Department of Biostatistics, University of Michigan
Hojoong Kwak: Department of Molecular Biology and Genetics, Cornell University

DOI: https://doi.org/10.1038/s41467-020-19829-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

Read online

Enhancer RNAs are transcribed bidirectionally from core transcription initiation regions. Here, by employing nascent RNA sequencing, the authors identify quantitative trait loci (QTLs) associated with enhancer RNA level and directionality, revealing the bipartite architecture of enhancers.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal