Nature Communications (Jun 2021)
Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance
- Haohao Huang,
- Songyang Zhang,
- Yuanyuan Li,
- Zhaodan Liu,
- Lanjuan Mi,
- Yan Cai,
- Xinzheng Wang,
- Lishu Chen,
- Haowen Ran,
- Dake Xiao,
- Fangye Li,
- Jiaqi Wu,
- Tingting Li,
- Qiuying Han,
- Liang Chen,
- Xin Pan,
- Huiyan Li,
- Tao Li,
- Kun He,
- Ailing Li,
- Xuemin Zhang,
- Tao Zhou,
- Qing Xia,
- Jianghong Man
Affiliations
- Haohao Huang
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Songyang Zhang
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Yuanyuan Li
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Zhaodan Liu
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Lanjuan Mi
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Yan Cai
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Xinzheng Wang
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Lishu Chen
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Haowen Ran
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Dake Xiao
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Fangye Li
- Department of Neurosurgery, First Medical Center of PLA General Hospital
- Jiaqi Wu
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Tingting Li
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Qiuying Han
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Liang Chen
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Xin Pan
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Huiyan Li
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Tao Li
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Kun He
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Ailing Li
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Xuemin Zhang
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Tao Zhou
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Qing Xia
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Jianghong Man
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- DOI
- https://doi.org/10.1038/s41467-021-24108-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
How ROS levels are regulated in cancer stem cells and their contribution to cancer resistance is currently not clear. Here, the authors show that prohibitin regulates mitochondrial ROS production stabilizing the peroxidase PRDX3 and this accounts for radiotherapy resistance in glioma stem-like cells.
