Communications Biology (Jan 2021)
Genome-wide study of a Neolithic Wartberg grave community reveals distinct HLA variation and hunter-gatherer ancestry
- Alexander Immel,
- Federica Pierini,
- Christoph Rinne,
- John Meadows,
- Rodrigo Barquera,
- András Szolek,
- Julian Susat,
- Lisa Böhme,
- Janina Dose,
- Joanna Bonczarowska,
- Clara Drummer,
- Katharina Fuchs,
- David Ellinghaus,
- Jan Christian Kässens,
- Martin Furholt,
- Oliver Kohlbacher,
- Sabine Schade-Lindig,
- Andre Franke,
- Stefan Schreiber,
- Johannes Krause,
- Johannes Müller,
- Tobias L. Lenz,
- Almut Nebel,
- Ben Krause-Kyora
Affiliations
- Alexander Immel
- Institute of Clinical Molecular Biology, Kiel University
- Federica Pierini
- Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology
- Christoph Rinne
- Institute of Pre- and Protohistoric Archaeology, Kiel University
- John Meadows
- Leibniz Laboratory for AMS Dating and Isotope Research, Kiel University
- Rodrigo Barquera
- Max Planck Institute for the Science of Human History
- András Szolek
- Applied Bioinformatics, Department for Computer Science, University of Tübingen
- Julian Susat
- Institute of Clinical Molecular Biology, Kiel University
- Lisa Böhme
- Institute of Clinical Molecular Biology, Kiel University
- Janina Dose
- Institute of Clinical Molecular Biology, Kiel University
- Joanna Bonczarowska
- Institute of Clinical Molecular Biology, Kiel University
- Clara Drummer
- Institute of Pre- and Protohistoric Archaeology, Kiel University
- Katharina Fuchs
- Institute of Clinical Molecular Biology, Kiel University
- David Ellinghaus
- Institute of Clinical Molecular Biology, Kiel University
- Jan Christian Kässens
- Institute of Clinical Molecular Biology, Kiel University
- Martin Furholt
- Department of Archaeology, Conservation and History, University of Oslo
- Oliver Kohlbacher
- Applied Bioinformatics, Department for Computer Science, University of Tübingen
- Sabine Schade-Lindig
- Landesamt für Denkmalpflege Hessen, hessenARCHÄOLOGIE, Schloss Biebrich
- Andre Franke
- Institute of Clinical Molecular Biology, Kiel University
- Stefan Schreiber
- Institute of Clinical Molecular Biology, Kiel University
- Johannes Krause
- Max Planck Institute for the Science of Human History
- Johannes Müller
- Institute of Pre- and Protohistoric Archaeology, Kiel University
- Tobias L. Lenz
- Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology
- Almut Nebel
- Institute of Clinical Molecular Biology, Kiel University
- Ben Krause-Kyora
- Institute of Clinical Molecular Biology, Kiel University
- DOI
- https://doi.org/10.1038/s42003-020-01627-4
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 10
Abstract
Alexander Immel et al. performed genome-wide analyses of 42 individuals from a collective burial in Niedertiefenbach, Germany from the Wartberg Culture. The authors find that this population had a large hunter-gatherer ancestry component and a distinct HLA pool, which indicates immune defenses against viral pathogens.
