Research progress on the role of TLR2 in the development of gastrointestinal cancer

Abstract

Toll-like receptor 2 (TLR2) is a pattern recognition receptor (PRR) that mediates immune and inflammatory responses, angiogenesis, and other physiological processes using the TLR2-MyD88 pathway. It is expressed on the cell surface, activated by exogenous PAMPs and endogenous DAMPs, and mediates the development of gastrointestinal cancer by regulating nuclear RNA expression through classical and non-classical signaling pathways such as MyD88, PI3K/Akt, Wnt/β-catenin, and MAPK.

Keywords

• tlr2|cancer|gastrointestinal cancer