Hypothalamic Rax+ tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice

Wenhui Mu; Si Li; Jingkai Xu; Xize Guo; Haoda Wu; Zhenhua Chen; Lianyong Qiao; Gisela Helfer; Falong Lu; Chong Liu; Qing-Feng Wu

doi:10.1038/s41467-021-22640-z

Nature Communications (Apr 2021)

Hypothalamic Rax+ tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice

Wenhui Mu,
Si Li,
Jingkai Xu,
Xize Guo,
Haoda Wu,
Zhenhua Chen,
Lianyong Qiao,
Gisela Helfer,
Falong Lu,
Chong Liu,
Qing-Feng Wu

Affiliations

Wenhui Mu: State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Si Li: State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Jingkai Xu: State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Xize Guo: State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Haoda Wu: State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Zhenhua Chen: State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Lianyong Qiao: State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Gisela Helfer: School of Chemistry and Biosciences, University of Bradford
Falong Lu: State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Chong Liu: Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University
Qing-Feng Wu: State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-021-22640-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Tanycytes contribute to the regulation of multiple hypothalamic functions. Here the authors investigate the regenerative and tumorigenic potential of adult Rax+ tanycytes in the median eminence in the context of the stem cell niche in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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