Formal Single Atom Editing of the Glycosylated Natural Product Fidaxomicin Improves Acid Stability and Retains Antibiotic Activity

• Isabella Ferrara,
• Gleb A. Chesnokov,
• Silvia Dittmann,
• Olivier Blacque,
• Susanne Sievers,
• Karl Gademann

Affiliations

Isabella Ferrara

Department of Chemistry, University of Zurich, Zürich, Switzerland

Gleb A. Chesnokov

Department of Chemistry, University of Zurich, Zürich, Switzerland

Silvia Dittmann

Department for Microbial Physiology and Molecular Biology, Institute of Microbiology, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany

Olivier Blacque

Department of Chemistry, University of Zurich, Zürich, Switzerland

Susanne Sievers

Department for Microbial Physiology and Molecular Biology, Institute of Microbiology, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany

Karl Gademann

Department of Chemistry, University of Zurich, Zürich, Switzerland