The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications

Randa M. Breikaa; Randa M. Breikaa; Brenda Lilly; Brenda Lilly

doi:10.3389/fcvm.2021.681948

Frontiers in Cardiovascular Medicine (May 2021)

The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications

Randa M. Breikaa,
Randa M. Breikaa,
Brenda Lilly,
Brenda Lilly

Affiliations

Randa M. Breikaa: Center for Cardiovascular Research and The Heart Center, Nationwide Children's Hospital, Columbus, OH, United States
Randa M. Breikaa: Molecular, Cellular and Developmental Biology Program, The Ohio State University, Columbus, OH, United States
Brenda Lilly: Center for Cardiovascular Research and The Heart Center, Nationwide Children's Hospital, Columbus, OH, United States
Brenda Lilly: Department of Pediatrics, The Ohio State University, Columbus, OH, United States

DOI: https://doi.org/10.3389/fcvm.2021.681948
Journal volume & issue: Vol. 8

Abstract

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COVID-19 is associated with a large number of cardiovascular sequelae, including dysrhythmias, myocardial injury, myocarditis and thrombosis. The Notch pathway is one likely culprit leading to these complications due to its direct role in viral entry, inflammation and coagulation processes, all shown to be key parts of COVID-19 pathogenesis. This review highlights links between the pathophysiology of SARS-CoV2 and the Notch signaling pathway that serve as primary drivers of the cardiovascular complications seen in COVID-19 patients.

Published in Frontiers in Cardiovascular Medicine

ISSN: 2297-055X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.frontiersin.org/journals/cardiovascular-medicine

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Abstract

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