Multistep orthophosphate release tunes actomyosin energy transduction

Luisa Moretto; Marko Ušaj; Oleg Matusovsky; Dilson E. Rassier; Ran Friedman; Alf Månsson

doi:10.1038/s41467-022-32110-9

Nature Communications (Aug 2022)

Multistep orthophosphate release tunes actomyosin energy transduction

Luisa Moretto,
Marko Ušaj,
Oleg Matusovsky,
Dilson E. Rassier,
Ran Friedman,
Alf Månsson

Affiliations

Luisa Moretto: Department of Chemistry and Biomedical Sciences, Linnaeus University
Marko Ušaj: Department of Chemistry and Biomedical Sciences, Linnaeus University
Oleg Matusovsky: Department of Kinesiology and Physical Education, McGill University
Dilson E. Rassier: Department of Kinesiology and Physical Education, McGill University
Ran Friedman: Department of Chemistry and Biomedical Sciences, Linnaeus University
Alf Månsson: Department of Chemistry and Biomedical Sciences, Linnaeus University

DOI: https://doi.org/10.1038/s41467-022-32110-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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Release of the ATP hydrolysis product orthophosphate (Pi) from the myosin active site is central in force generation but is poorly understood. Here, Moretto et al. present evidence for multistep Pi-release reconciling apparently contradictory results.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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